Mossy fiber sprouting in rats hippocampus of subclinical seizures following hypoxic brain injury
نویسندگان
چکیده
1 Department of Neurology, Luzhou Medical College, Luzhou, 646000, China 2 Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, TX 77204, USA 3 Department of Neurology, The first affiliated hospital of Chongqing medical university, Chongqing, 40016, China 4 Department of otolaryngology, Guizhou Provincial People's Hospital, Guiyang, 550002, China 5 Department of Neurology, The second affiliated hospital of Chongqing medical university, Chongqing, 40010
منابع مشابه
اثر عصاره الکلی سیاه‌دانه بر هیپوکمپ در موش صحرایی با صرع لب گیجگاهی
Background and Objective: Pathologically, temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. Considering some evidences on neuroprotective and antioxidant activity Nigella sativa (NS), this study was undertaken to evaluate the preventive effect of NS on structural changes in hippocampus of kainate-epileptic rat...
متن کاملRelations between brain pathology and temporal lobe epilepsy.
Temporal lobe epilepsy, the most common type of epilepsy in adult humans, is characterized clinically by the progressive development of spontaneous recurrent seizures of temporal lobe origin and pathologically by hippocampal neuronal loss and mossy fiber sprouting. In this study, we sought to test the prominent hypothesis that neuronal loss and mossy fiber sprouting play a critical role in the ...
متن کاملDevelopment of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures.
PURPOSE To study the development of epilepsy following hypoxia-induced neonatal seizures in Long-Evans rats and to establish the presence of spontaneous seizures in this model of early life seizures. METHODS Long-Evans rat pups were subjected to hypoxia-induced neonatal seizures at postnatal day 10 (P10). Epidural cortical electroencephalography (EEG) and hippocampal depth electrodes were use...
متن کاملاثر استیل آل کارنیتین در جلوگیری از تحلیل نورون‌های هیپوکمپ و جوانه زدن فیبرهای خزه‌ای در مدل تجربی صرع گیجگاهی در موش صحرایی
Background & Aims : Temporal lobe epilepsy is due to structural and metabolic changes in hippocampus including marked degeneration of neurons. Considering some evidences on antiepileptic and neuroprotective activity of acetyl L carnitine (ALC), this study was undertaken to evaluate the preventive effect of ALC on structural changes in hippocampus in an experimental model of temporal lobe ep...
متن کاملPii: S0306-4522(98)00289-9
-Stress, which can precipitate and exacerbate depression, causes atrophy and in severe cases death of hippocampal neurons. Atrophy of the hippocampus has also been observed in patients suffering from recurrent major depression. The present study examines the influence of electroconvulsive seizures, one of the most effective treatments for depression, on the morphology and survival of hippocampa...
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